Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which hypercholesterolemia produces a procoagulant state remain undefined. Atheroscleros...

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Detalhes bibliográficos
Main Authors: Owens, A. Phillip, Passam, Freda H., Antoniak, Silvio, Marshall, Stephanie M., McDaniel, Allison L., Rudel, Lawrence, Williams, Julie C., Hubbard, Brian K., Dutton, Julie-Ann, Wang, Jianguo, Tobias, Peter S., Curtiss, Linda K., Daugherty, Alan, Kirchhofer, Daniel, Luyendyk, James P., Moriarty, Patrick M., Nagarajan, Shanmugam, Furie, Barbara C., Furie, Bruce, Johns, Douglas G., Temel, Ryan E., Mackman, Nigel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266787/
https://ncbi.nlm.nih.gov/pubmed/22214850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58969
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