Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which hypercholesterolemia produces a procoagulant state remain undefined. Atheroscleros...

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Autors principals: Owens, A. Phillip, Passam, Freda H., Antoniak, Silvio, Marshall, Stephanie M., McDaniel, Allison L., Rudel, Lawrence, Williams, Julie C., Hubbard, Brian K., Dutton, Julie-Ann, Wang, Jianguo, Tobias, Peter S., Curtiss, Linda K., Daugherty, Alan, Kirchhofer, Daniel, Luyendyk, James P., Moriarty, Patrick M., Nagarajan, Shanmugam, Furie, Barbara C., Furie, Bruce, Johns, Douglas G., Temel, Ryan E., Mackman, Nigel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266787/
https://ncbi.nlm.nih.gov/pubmed/22214850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58969
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