Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which hypercholesterolemia produces a procoagulant state remain undefined. Atheroscleros...

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Bibliographic Details
Main Authors: Owens, A. Phillip, Passam, Freda H., Antoniak, Silvio, Marshall, Stephanie M., McDaniel, Allison L., Rudel, Lawrence, Williams, Julie C., Hubbard, Brian K., Dutton, Julie-Ann, Wang, Jianguo, Tobias, Peter S., Curtiss, Linda K., Daugherty, Alan, Kirchhofer, Daniel, Luyendyk, James P., Moriarty, Patrick M., Nagarajan, Shanmugam, Furie, Barbara C., Furie, Bruce, Johns, Douglas G., Temel, Ryan E., Mackman, Nigel
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266787/
https://ncbi.nlm.nih.gov/pubmed/22214850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58969
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