Genetic Reevaluation of the Role of F-Box Proteins in Cyclin D1 Degradation

D-type cyclins play a pivotal role in G(1)-S progression of the cell cycle, and their expression is frequently deregulated in cancer. Cyclin D1 has a half-life of only ∼30 min as a result of its ubiquitylation and proteasomal degradation, with various F-box proteins, including Fbxo4, Fbxw8, Skp2, an...

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Hlavní autoři: Kanie, Tomoharu, Onoyama, Ichiro, Matsumoto, Akinobu, Yamada, Masanori, Nakatsumi, Hirokazu, Tateishi, Yuki, Yamamura, So, Tsunematsu, Ryosuke, Matsumoto, Masaki, Nakayama, Keiichi I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266600/
https://ncbi.nlm.nih.gov/pubmed/22124152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06570-11
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