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Genetic Reevaluation of the Role of F-Box Proteins in Cyclin D1 Degradation
D-type cyclins play a pivotal role in G(1)-S progression of the cell cycle, and their expression is frequently deregulated in cancer. Cyclin D1 has a half-life of only ∼30 min as a result of its ubiquitylation and proteasomal degradation, with various F-box proteins, including Fbxo4, Fbxw8, Skp2, an...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266600/ https://ncbi.nlm.nih.gov/pubmed/22124152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06570-11 |
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