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The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict
APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses. HIV and related primate lentiviruses encode Vif, which counteracts A3G by inducing its degradation. This Vif-mediated A3G inhibition is species-specific, suggesting that the A3G-Vif interaction has evolved as primate lentiviruse...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266539/ https://ncbi.nlm.nih.gov/pubmed/22264516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.11.010 |
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