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The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict

APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses. HIV and related primate lentiviruses encode Vif, which counteracts A3G by inducing its degradation. This Vif-mediated A3G inhibition is species-specific, suggesting that the A3G-Vif interaction has evolved as primate lentiviruse...

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Bibliografiske detaljer
Main Authors: Compton, Alex A., Hirsch, Vanessa M., Emerman, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266539/
https://ncbi.nlm.nih.gov/pubmed/22264516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.11.010
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