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Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression

Metabolic memory (MM) is the phenomenon whereby diabetes complications persist and progress after glycemic recovery is achieved. Here, we present data showing that MM is heritable and that the transmission correlates with hyperglycemia-induced DNA hypomethylation and aberrant gene expression. Strept...

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Autori principali: Olsen, Ansgar S., Sarras, Michael P., Leontovich, Alexey, Intine, Robert V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266410/
https://ncbi.nlm.nih.gov/pubmed/22228713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0588
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