Fetal and Neonatal Goiter in Cynomolgus Monkeys Following Administration of the Antithyroid Drug Thiamazole at High Doses to Dams During Pregnancy

To evaluate morphologic alterations in the thyroid gland in the second generation in cynomolgus monkeys, pregnant dams were exposed to high doses of thiamazole. In Experiment A, dams received thiamazole intragastrically via a nasogastric catheter from gestation day (GD) 50 to GD 150 or on the day be...

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Autors principals: Yoshikawa, Tsuyoshi, Moriyama, Akiko, Kodama, Rinya, Sasaki, Yuji, Sunagawa, Tatsumi, Okazaki, Takanobu, Urashima, Asami, Nishida, Yoshiro, Arima, Akihiro, Inoue, Ayumi, Negishi, Takayuki, Yoshikawa, Yasuhiro, Ihara, Toshio, Maeda, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: The Japanese Society of Toxicologic Pathology 2011
Matèries:
Original
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266356/
https://ncbi.nlm.nih.gov/pubmed/22319233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.24.215
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