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Extension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism

Upregulation of kynurenine (KYN) formation from tryptophan (TRY) was associated with aging in animal and human studies. TRY-KYN metabolism is affected by the activities of TRY 2,3-dioxygenase 2 (TDO) and AT P-binding cassette (ABC) transporter regulating TRY access to intracellular TDO. We studied t...

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Autors principals: Oxenkrug, Gregory, Navrotskaya, Valeriya, Vorobyova, Lyudmila, Summergrad, Paul
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266072/
https://ncbi.nlm.nih.gov/pubmed/22041575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/fly.5.4.18414
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