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Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation
High expression of the mitotic kinase Bub1 is associated with a variety of human cancers and correlates with poor clinical prognosis, but whether Bub1 alone can drive tumorigenesis was unknown. We provided conclusive evidence that Bub1 has oncogenic properties by generating transgenic mice that over...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266005/ https://ncbi.nlm.nih.gov/pubmed/22033440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.21.18156 |
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