Pro-nerve Growth Factor Induces Autocrine Stimulation of Breast Cancer Cell Invasion through Tropomyosin-related Kinase A (TrkA) and Sortilin Protein

The precursor of nerve growth factor (proNGF) has been described as a biologically active polypeptide able to induce apoptosis in neuronal cells, via the neurotrophin receptor p75(NTR) and the sortilin receptor. Herein, it is shown that proNGF is produced and secreted by breast cancer cells, stimula...

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Bibliographic Details
Main Authors: Demont, Yohann, Corbet, Cyril, Page, Adeline, Ataman-Önal, Yasemin, Choquet-Kastylevsky, Genevieve, Fliniaux, Ingrid, Le Bourhis, Xuefen, Toillon, Robert-Alain, Bradshaw, Ralph A., Hondermarck, Hubert
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265873/
https://ncbi.nlm.nih.gov/pubmed/22128158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211714
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