Supercharging Protein Complexes from Aqueous Solution Disrupts their Native Conformations

The effects of aqueous solution supercharging on the solution- and gas-phase structures of two protein complexes were investigated using traveling-wave ion mobility-mass spectrometry (TWIMS-MS). Low initial concentrations of m-nitrobenzyl alcohol (m-NBA) in the electrospray ionization (ESI) solution...

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Main Authors: Sterling, Harry J., Kintzer, Alexander F., Feld, Geoffrey K., Cassou, Catherine A., Krantz, Bryan A., Williams, Evan R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265691/
https://ncbi.nlm.nih.gov/pubmed/22161509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-011-0301-y
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