Structure–Function Studies Using Deletion Mutants Identify Domains of gC1qR/p33 as Potential Therapeutic Targets for Vascular Permeability and Inflammation

The endothelial cell receptor complex for kininogen (HK) comprises gC1qR, cytokeratin 1, and urokinase-type plasminogen activator receptor and is essential for activation of the kinin system that leads to bradykinin (BK) generation. Of these, gC1qR/p33 constitutes a high affinity site for HK – the B...

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Hauptverfasser: Ghebrehiwet, Berhane, Jesty, Jolyon, Xu, Sulan, Vinayagasundaram, Rama, Vinayagasundaram, Uma, Ji, Yan, Valentino, Alisa, Hosszu, Kinga K., Mathew, Sally, Joseph, Kusumam, Kaplan, Allen P., Peerschke, Ellinor I. B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Research Foundation 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265123/
https://ncbi.nlm.nih.gov/pubmed/22282702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00058
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