Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug

PURPOSE: To demonstrate drug/polymer nanoparticles can increase the rate and extent of oral absorption of a low-solubility, high-permeability drug. METHODS: Amorphous drug/polymer nanoparticles containing celecoxib were prepared using ethyl cellulose and either sodium caseinate or bile salt. Nanopar...

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Detalhes bibliográficos
Main Authors: Morgen, Michael, Bloom, Corey, Beyerinck, Ron, Bello, Akintunde, Song, Wei, Wilkinson, Karen, Steenwyk, Rick, Shamblin, Sheri
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264876/
https://ncbi.nlm.nih.gov/pubmed/21863477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0558-7
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