Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity

BACKGROUND: Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is assoc...

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Detalhes bibliográficos
Main Authors: Kakinohana, Osamu, Hefferan, Michael P., Miyanohara, Atsushi, Nejime, Tetsuya, Marsala, Silvia, Juhas, Stefan, Juhasova, Jana, Motlik, Jan, Kucharova, Karolina, Strnadel, Jan, Platoshyn, Oleksandr, Lazar, Peter, Galik, Jan, Vinay, Laurent, Marsala, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264568/
https://ncbi.nlm.nih.gov/pubmed/22291989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030561
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