Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity

BACKGROUND: Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is assoc...

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Main Authors: Kakinohana, Osamu, Hefferan, Michael P., Miyanohara, Atsushi, Nejime, Tetsuya, Marsala, Silvia, Juhas, Stefan, Juhasova, Jana, Motlik, Jan, Kucharova, Karolina, Strnadel, Jan, Platoshyn, Oleksandr, Lazar, Peter, Galik, Jan, Vinay, Laurent, Marsala, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264568/
https://ncbi.nlm.nih.gov/pubmed/22291989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030561
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