Activation of the Ras/Raf/MEK Pathway Facilitates Hepatitis C Virus Replication via Attenuation of the Interferon-JAK-STAT Pathway

Hepatitis C virus (HCV) is a major cause of chronic liver diseases worldwide, often leading to the development of hepatocellular carcinoma (HCC). Constitutive activation of the Ras/Raf/MEK pathway is responsible for approximately 30% of cancers. Here we attempted to address the correlation between a...

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Detalhes bibliográficos
Main Authors: Zhang, Qi, Gong, Rui, Qu, Jing, Zhou, Yijing, Liu, Weiyong, Chen, Mingzhou, Liu, Yingle, Zhu, Ying, Wu, Jianguo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264379/
https://ncbi.nlm.nih.gov/pubmed/22114332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00688-11
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