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Overton's Rule Helps To Estimate the Penetration of Anti-Infectives into Patients' Cerebrospinal Fluid

In 1900, Ernst Overton found that the entry of anilin dyes through the cell membranes of living cells depended on the lipophilicity of the dyes. The brain is surrounded by barriers consisting of lipid layers that possess several inward and outward active transport systems. In the absence of meningea...

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Bibliografski detalji
Glavni autori: Djukic, Marija, Munz, Martin, Sörgel, Fritz, Holzgrabe, Ulrike, Eiffert, Helmut, Nau, Roland
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264201/
https://ncbi.nlm.nih.gov/pubmed/22106225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00437-11
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