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Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

Summary: The entry of anti-infectives into the central nervous system (CNS) depends on the compartment studied, molecular size, electric charge, lipophilicity, plasma protein binding, affinity to active transport systems at the blood-brain/blood-cerebrospinal fluid (CSF) barrier, and host factors su...

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Main Authors: Nau, Roland, Sörgel, Fritz, Eiffert, Helmut
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952976/
https://ncbi.nlm.nih.gov/pubmed/20930076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CMR.00007-10
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