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Repression of Aryl Hydrocarbon Receptor (AHR) Signaling by AHR Repressor: Role of DNA Binding and Competition for AHR Nuclear Translocator

Activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin causes altered gene expression and toxicity. The AHR repressor (AHRR) inhibits AHR signaling through a proposed mechanism involving competition with AHR for dimerization with AHR nuclear translocator (ARNT) and...

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Autores principales: Evans, Brad R., Karchner, Sibel I., Allan, Lenka L., Pollenz, Richard S., Tanguay, Robert L., Jenny, Matthew J., Sherr, David H., Hahn, Mark E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263532/
https://ncbi.nlm.nih.gov/pubmed/18000031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.040204
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