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Exploiting the Diversity of the Heat-Shock Protein Family for Primary and Secondary Tauopathy Therapeutics

The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer’s disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule ass...

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Autori principali: Abisambra, Jose F, Jinwal, Umesh K, Jones, Jeffrey R, Blair, Laura J, Koren, John, Dickey, Chad A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bentham Science Publishers 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263456/
https://ncbi.nlm.nih.gov/pubmed/22654720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/157015911798376226
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