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Structure, dynamics and binding of the LA45 module pair of the Low Density Lipoprotein Receptor suggest an important role for LA4 in ligand release

The Low Density Lipoprotein Receptor (LDLR), the primary receptor for cholesterol uptake, binds ligands through its seven LDL-A modules (LAs). We present NMR and ligand binding measurements on the fourth and fifth modules of the LDLR (LA45), the modules critical for ApoE binding, at physiological pH...

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Main Authors: Guttman, Miklos, Komives, Elizabeth A.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263374/
https://ncbi.nlm.nih.gov/pubmed/22091758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2014486
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