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Structure, dynamics and binding of the LA45 module pair of the Low Density Lipoprotein Receptor suggest an important role for LA4 in ligand release

The Low Density Lipoprotein Receptor (LDLR), the primary receptor for cholesterol uptake, binds ligands through its seven LDL-A modules (LAs). We present NMR and ligand binding measurements on the fourth and fifth modules of the LDLR (LA45), the modules critical for ApoE binding, at physiological pH...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Guttman, Miklos, Komives, Elizabeth A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263374/
https://ncbi.nlm.nih.gov/pubmed/22091758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2014486
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