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Therapeutic PD-L1 and LAG-3 blockade rapidly clears established blood-stage Plasmodium infection
Plasmodium infection of erythrocytes induces clinical malaria. Parasite-specific CD4(+) T cells correlate with reduced parasite burdens and severity of human malaria, and are required to control blood-stage infection in mice. However, the characteristics of CD4(+) T cells that determine protection o...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262959/ https://ncbi.nlm.nih.gov/pubmed/22157630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2180 |
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