TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9

Pathogens may signal through multiple TLRs with synergistic or antagonistic effects on the induction of cytokines, including type I IFN (IFN-I). IFN-I is typically induced by TLR9 but not TLR2. Moreover, we previously reported that TLR2 signaling by Mycobacterium tuberculosis or other TLR2 agonists...

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Bibliographic Details
Main Authors: Liu, Yi C., Simmons, Daimon P., Li, Xiaoxia, Abbott, Derek W., Boom, W. Henry, Harding, Clifford V.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262948/
https://ncbi.nlm.nih.gov/pubmed/22227568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102181
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