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p38α signaling programs dendritic cells to drive T(H)17 cell differentiation and autoimmune inflammation
Dendritic cells (DCs) bridge innate and adaptive immunity, but how DC-derived signals regulate T cell lineage choices remains unclear. We report that p38α MAP kinase programs DCs to drive T(H)17 differentiation. Deletion of p38α in DCs, but not macrophages or T cells, protects mice from T(H)17-media...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262925/ https://ncbi.nlm.nih.gov/pubmed/22231518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2207 |
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