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Predicting the in vivo Mechanism of Action for Drug Leads using NMR Metabolomics
New strategies are needed to circumvent increasing outbreaks of resistant strains of pathogens and to expand the dwindling supply of effective antimicrobials. A common impediment to drug development is the lack of an easy approach to determine the in vivo mechanism of action and efficacy of novel dr...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262886/ https://ncbi.nlm.nih.gov/pubmed/22007661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200348m |
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