Copper Deficiency Induced Emphysema Is Associated with Focal Adhesion Kinase Inactivation

BACKGROUND: Copper is an important regulator of hypoxia inducible factor 1 alpha (HIF-1α) dependent vascular endothelial growth factor (VEGF) expression, and is also required for the activity of lysyl oxidase (LOX) to effect matrix protein cross-linking. Cell detachment from the extracellular matrix...

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Main Authors: Mizuno, Shiro, Yasuo, Masanori, Bogaard, Harm J., Kraskauskas, Donatas, Alhussaini, Aysar, Gomez-Arroyo, Jose, Farkas, Daniela, Farkas, Laszlo, Voelkel, Norbert F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262830/
https://ncbi.nlm.nih.gov/pubmed/22276220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030678
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