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Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPARγ

Impairments in mitochondria and transcription are important factors in the pathogenesis of Huntington disease (HD), a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. This study investigated the effect of different metabolic states and peroxisome proliferator-...

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Sonraí Bibleagrafaíochta
Main Authors: Jin, Youngnam N., Hwang, Woong Y., Jo, Chulman, Johnson, Gail V. W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262812/
https://ncbi.nlm.nih.gov/pubmed/22276192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030406
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