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Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer

The epidermal growth factor receptor 2 (HER2) is a tyrosine kinase overexpressed in nearly 20% to 25% of invasive breast cancers. Trastuzumab is a humanized monoclonal antibody that targets HER2. The majority of patients with metastatic breast cancer initially respond to trastuzumab, however, within...

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Autori principali: Fiszman, Gabriel L., Jasnis, María A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE-Hindawi Access to Research 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262573/
https://ncbi.nlm.nih.gov/pubmed/22295219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/352182
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