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Cryoprotection–lyophilization and physical stabilization of rifampicin-loaded flower-like polymeric micelles

Rifampicin-loaded poly(ε-caprolactone)–b-poly(ethylene glycol)–poly(ε-caprolactone) flower-like polymeric micelles display low aqueous physical stability over time and undergo substantial secondary aggregation. To improve their physical stability, the lyoprotection–lyophilization process was thoroug...

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Detalhes bibliográficos
Main Authors: Moretton, Marcela A., Chiappetta, Diego A., Sosnik, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262430/
https://ncbi.nlm.nih.gov/pubmed/21865255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2011.0414
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