Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Genome-wide association studies have identified 32 loci associated with body mass index (BMI), a measure that does not allow distinguishing lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals, and fol...

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Main Authors: Kilpeläinen, Tuomas O, Zillikens, M Carola, Stančáková, Alena, Finucane, Francis M, Ried, Janina S, Langenberg, Claudia, Zhang, Weihua, Beckmann, Jacques S, Luan, Jian’an, Vandenput, Liesbeth, Styrkarsdottir, Unnur, Zhou, Yanhua, Smith, Albert Vernon, Zhao, Jing-Hua, Amin, Najaf, Vedantam, Sailaja, Shin, So Youn, Haritunians, Talin, Fu, Mao, Feitosa, Mary F, Kumari, Meena, Halldorsson, Bjarni V, Tikkanen, Emmi, Mangino, Massimo, Hayward, Caroline, Song, Ci, Arnold, Alice M, Aulchenko, Yurii S, Oostra, Ben A, Campbell, Harry, Cupples, L Adrienne, Davis, Kathryn E, Döring, Angela, Eiriksdottir, Gudny, Estrada, Karol, Fernández-Real, José Manuel, Garcia, Melissa, Gieger, Christian, Glazer, Nicole L, Guiducci, Candace, Hofman, Albert, Humphries, Steve E, Isomaa, Bo, Jacobs, Leonie C, Jula, Antti, Karasik, David, Karlsson, Magnus K, Khaw, Kay-Tee, Kim, Lauren J, Kivimäki, Mika, Klopp, Norman, Kühnel, Brigitte, Kuusisto, Johanna, Liu, Yongmei, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, McKnight, Barbara, Mellström, Dan, Mitchell, Braxton D, Mooser, Vincent, Moreno, José Maria, Männistö, Satu, O’Connell, Jeffery R, Pascoe, Laura, Peltonen, Leena, Peral, Belén, Perola, Markus, Psaty, Bruce M, Salomaa, Veikko, Savage, David B, Semple, Robert K, Skaric-Juric, Tatjana, Sigurdsson, Gunnar, Song, Kijoung S, Spector, Timothy D, Syvänen, Ann-Christine, Talmud, Philippa J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Uitterlinden, André G, van Duijn, Cornelia M, Vidal-Puig, Antonio, Wild, Sarah H, Wright, Alan F, Clegg, Deborah J, Schadt, Eric, Wilson, James F, Rudan, Igor, Ripatti, Samuli, Borecki, Ingrid B, Shuldiner, Alan R, Ingelsson, Erik, Jansson, John-Olov, Kaplan, Robert C, Gudnason, Vilmundur, Harris, Tamara B, Groop, Leif, Kiel, Douglas P, Rivadeneira, Fernando, Walker, Mark, Barroso, Inês, Vollenweider, Peter, Waeber, Gérard, Chambers, John C, Kooner, Jaspal S, Soranzo, Nicole, Hirschhorn, Joel N, Stefansson, Kari, Wichmann, H-Erich, Ohlsson, Claes, O’Rahilly, Stephen, Wareham, Nicholas J, Speliotes, Elizabeth K, Fox, Caroline S, Laakso, Markku, Loos, Ruth J F
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262230/
https://ncbi.nlm.nih.gov/pubmed/21706003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.866
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