Impaired Chromatin Remodelling at STAT1-Regulated Promoters Leads to Global Unresponsiveness of Toxoplasma gondii-Infected Macrophages to IFN-γ

Intracellular pathogens including the apicomplexan and opportunistic parasite Toxoplasma gondii profoundly modify their host cells in order to establish infection. We have shown previously that intracellular T. gondii inhibit up-regulation of regulatory and effector functions in murine macrophages (...

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Autors principals: Lang, Christine, Hildebrandt, Anke, Brand, Franziska, Opitz, Lennart, Dihazi, Hassan, Lüder, Carsten G. K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262016/
https://ncbi.nlm.nih.gov/pubmed/22275866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002483
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