HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection

Nucleoside analogs (NAs) are used to treat numerous viral infections and cancer. They compete with endogenous nucleotides (dNTP/NTP) for incorporation into nascent DNA/RNA and inhibit replication by preventing subsequent primer extension. To date, an integrated mathematical model that could allow th...

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Autores principales: von Kleist, Max, Metzner, Philipp, Marquet, Roland, Schütte, Christof
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261923/
https://ncbi.nlm.nih.gov/pubmed/22275860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002359
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