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Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor
The first structural and biophysical data on the folate biosynthesis pathway enzyme and drug target, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (SaHPPK), from the pathogen Staphylococcus aureus is presented. HPPK is the second essential enzyme in the pathway catalysing the pyrophosphoryl tr...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261883/ https://ncbi.nlm.nih.gov/pubmed/22276115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029444 |
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