Autocrine Prostaglandin E(2) Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma

BACKGROUND: Prostaglandin E(2) (PGE(2)) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investig...

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Detalhes bibliográficos
Main Authors: Rasmuson, Agnes, Kock, Anna, Fuskevåg, Ole Martin, Kruspig, Björn, Simón-Santamaría, Jaione, Gogvadze, Vladimir, Johnsen, John Inge, Kogner, Per, Sveinbjörnsson, Baldur
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261878/
https://ncbi.nlm.nih.gov/pubmed/22276108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029331
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