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Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells

The survival of motor neuron (SMN) protein plays an important role in the biogenesis of spliceosomal snRNPs and is one factor required for the integrity of nuclear Cajal bodies (CBs). CBs are enriched in small CB-specific (sca) RNAs, which guide the formation of pseudouridylated and 2′-O-methylated...

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Autori principali: Deryusheva, Svetlana, Choleza, Maria, Barbarossa, Adrien, Gall, Joseph G., Bordonné, Rémy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261741/
https://ncbi.nlm.nih.gov/pubmed/22124016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.030106.111
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