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Ground-state coordination of a catalytic metal to the scissile phosphate of a tertiary-stabilized Hammerhead ribozyme

Although the Hammerhead ribozyme (HHRz) has long been used as a model system in the field of ribozyme enzymology, several details of its mechanism are still not well understood. In particular, significant questions remain concerning the disposition and role of catalytic metals in the HHRz. Previous...

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Autors principals: Ward, W. Luke, DeRose, Victoria J.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261738/
https://ncbi.nlm.nih.gov/pubmed/22124015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.030239.111
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