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The role of EGF receptor ubiquitination in regulating its intracellular traffic

Progression of activated EGF receptor (EGFR) through the endocytic pathway regulates EGFR signaling. Here we show that a non-ubiquitinated EGFR mutant, unable to bind the endosomal sorting complex required for transport (ESCRT) component, Hrs, is not efficiently targeted onto intraluminal vesicles (...

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Bibliografiska uppgifter
Huvudupphovsmän: Eden, Emily R, Huang, Fangtian, Sorkin, Alexander, Futter, Clare E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261333/
https://ncbi.nlm.nih.gov/pubmed/22017370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2011.01305.x
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