Broadly directed virus-specific CD4(+) T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

Vigorous proliferative CD4(+) T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we comprehensively characterized the breadth, specificity, and quality of the HCV-spec...

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Autori principali: Schulze zur Wiesch, Julian, Ciuffreda, Donatella, Lewis-Ximenez, Lia, Kasprowicz, Victoria, Nolan, Brian E., Streeck, Hendrik, Aneja, Jasneet, Reyor, Laura L., Allen, Todd M., Lohse, Ansgar W., McGovern, Barbara, Chung, Raymond T., Kwok, William W., Kim, Arthur Y., Lauer, Georg M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260872/
https://ncbi.nlm.nih.gov/pubmed/22213804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100388
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