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Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B
Intramuscular (IM) administration of an adeno-associated viral (AAV) vector represents a simple and safe method of gene transfer for treatment of the X-linked bleeding disorder hemophilia B (factor IX, F.IX, deficiency). However, the approach is hampered by an increased risk of immune responses agai...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Research Foundation
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3260742/ https://ncbi.nlm.nih.gov/pubmed/22279442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2011.00244 |
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