Serum Oxidative Stress-Induced Repression of Nrf2 and GSH Depletion: A Mechanism Potentially Involved in Endothelial Dysfunction of Young Smokers

BACKGROUND: Although oxidative stress plays a major role in endothelial dysfunction (ED), the role of glutathione (GSH), of nuclear erythroid-related factor 2 (Nrf2) and of related antioxidant genes (ARE) are yet unknown. In this study we combined an in vivo with an in vitro model to assess whether...

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Detalhes bibliográficos
Main Authors: Fratta Pasini, Anna, Albiero, Anna, Stranieri, Chiara, Cominacini, Mattia, Pasini, Andrea, Mozzini, Chiara, Vallerio, Paola, Cominacini, Luciano, Garbin, Ulisse
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260271/
https://ncbi.nlm.nih.gov/pubmed/22272327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030291
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