Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells

BACKGROUND: CD44 is a major cellular receptor for hyaluronic acids. The stem structure of CD44 encoded by ten normal exons can be enlarged by ten variant exons (v1-v10) by alternative splicing. We have succeeded in preparing MV5 fully human IgM and its class-switched GV5 IgG monoclonal antibody (mAb...

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Main Authors: Masuko, Kazue, Okazaki, Shogo, Satoh, Mayumi, Tanaka, Goh, Ikeda, Tatsuya, Torii, Ryota, Ueda, Eri, Nakano, Takashi, Danbayashi, Masaaki, Tsuruoka, Tomoyo, Ohno, Yoshiya, Yagi, Hideki, Yabe, Noritsugu, Yoshida, Hideaki, Tahara, Tomoyuki, Kataoka, Shiro, Oshino, Taichi, Shindo, Takayuki, Niwa, Shin-ichiro, Ishimoto, Takatsugu, Baba, Hideo, Hashimoto, Yoshiyuki, Saya, Hideyuki, Masuko, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260170/
https://ncbi.nlm.nih.gov/pubmed/22272243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029728
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