Locally Generated Methylseleninic Acid Induces Specific Inactivation of Protein Kinase C Isoenzymes: RELEVANCE TO SELENIUM-INDUCED APOPTOSIS IN PROSTATE CANCER CELLS

In this study, we show that methylselenol, a selenometabolite implicated in cancer prevention, did not directly inactivate protein kinase C (PKC). Nonetheless, its oxidation product, methylseleninic acid (MSA), inactivated PKC at low micromolar concentrations through a redox modification of vicinal...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gundimeda, Usha, Schiffman, Jason Eric, Chhabra, Divya, Wong, Jourdan, Wu, Adela, Gopalakrishna, Rayudu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Mechanisms of Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259896/
https://ncbi.nlm.nih.gov/pubmed/18922790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807007200
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