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Carbon Monoxide Inhibits L-type Ca(2+) Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species
Conditions of stress, such as myocardial infarction, stimulate up-regulation of heme oxygenase (HO-1) to provide cardioprotection. Here, we show that CO, a product of heme catabolism by HO-1, directly inhibits native rat cardiomyocyte L-type Ca(2+) currents and the recombinant α(1C) subunit of the h...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259849/ https://ncbi.nlm.nih.gov/pubmed/18596041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803037200 |
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