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PAK Is Regulated by PI3K, PIX, CDC42, and PP2Cα and Mediates Focal Adhesion Turnover in the Hyperosmotic Stress-induced p38 Pathway
Fractionation of brain extracts and functional biochemical assays identified PP2Cα, a serine/threonine phosphatase, as the major biochemical activity inhibiting PAK1. PP2Cα dephosphorylated PAK1 and p38, both of which were activated upon hyperosmotic shock with the same kinetics. In comparison to gr...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259815/ https://ncbi.nlm.nih.gov/pubmed/18586681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801728200 |
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