Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

CD8(+) cytotoxic T lymphocytes (CTL) can recognize and kill target cells expressing only a few cognate major histocompatibility complex (MHC) I-peptide complexes. This high sensitivity requires efficient scanning of a vast number of highly diverse MHC I-peptide complexes by the T cell receptor in th...

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Main Authors: Segura, Jean-Manuel, Guillaume, Philippe, Mark, Silke, Dojcinovic, Danijel, Johannsen, Alexandre, Bosshard, Giovanna, Angelov, Georgi, Legler, Daniel F., Vogel, Horst, Luescher, Immanuel F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2008
Ábhair:
Mechanisms of Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259769/
https://ncbi.nlm.nih.gov/pubmed/18579518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803549200
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