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A Master Switch Couples Mg(2+)-Assisted Catalysis to Domain Motion in B. stearothermophilus Tryptophanyl-tRNA Synthetase
We demonstrate how Tryptophanyl-tRNA synthetase (TrpRS) uses conformation-dependent Mg(2+) activation to couple catalysis of tryptophan activation to specific, functional domain movements. Rate acceleration by Mg(2+) requires ~ -6.0 kcal/mole in protein•Mg(2+) interaction energy, none of which arise...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259537/ https://ncbi.nlm.nih.gov/pubmed/22244762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.10.020 |
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