Autoantibody Activation of Beta-Adrenergic and Muscarinic Receptors Contributes to an “Autoimmune” Orthostatic Hypotension: Receptor Autoantibodies in Orthostatic Hypotension

BACKGROUND: Orthostatic hypotension (OH) is characterized by an abnormal autonomic response to upright posture. Activating autoantibodies to β1/2-adrenergic (AAβ1/2AR) and M2/3 muscarinic receptors (AAM2/3R) produce vasodilative changes in the vasculature that may contribute to OH. METHODS AND RESUL...

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Autori principali: Yu, Xichun, Stavrakis, Stavros, Hill, Michael A., Huang, Shijun, Reim, Sean, Li, Hongliang, Khan, Muneer, Hamlett, Sean, Cunningham, Madeleine W., Kem, David C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259269/
https://ncbi.nlm.nih.gov/pubmed/22130180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jash.2011.10.003
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