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Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo

The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated gastrins in vitro and in vivo. Bi(3+) ions also bind to glycine-extended gastrin17 (Ggly), but inhibit Ggly-induced cell proliferation and migration in gast...

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Detalhes bibliográficos
Main Authors: Kovac, Suzana, Loh, Su-Wen, Lachal, Shamilah, Shulkes, Arthur, Baldwin, Graham S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259252/
https://ncbi.nlm.nih.gov/pubmed/22172990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.11.030
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