Increased efficiency of the GABAA and GABAB receptor–mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Cognitive impairment in Down syndrome (DS) involves the hippocampus. In the Ts65Dn mouse model of DS, deficits in hippocampus-dependent learning and synaptic plasticity were linked to enhanced inhibition. However, the mechanistic basis of changes in inhibitory efficiency remains largely unexplored,...

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Autori principali: Kleschevnikov, Alexander M., Belichenko, Pavel V., Gall, Jessica, George, Lizzy, Nosheny, Rachel, Maloney, Michael T., Salehi, Ahmad, Mobley, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259223/
https://ncbi.nlm.nih.gov/pubmed/22062771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.10.009
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